fa تحقيقي Original Paper <div> <p><strong>Abstract</strong></p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp; Background and Objective: </strong>Diabetes mellitus is the most common risk factor for coronary artery disease (CAD). Cholesteryl ester transfer protein (CETP) TaqIB polymorphism is associated with changes in lipid profile and may be a risk factor for CAD in patients with diabetes. This study aimed to evaluate the association of CETP TaqIB polymorphism with CAD in patients with type 2 diabetes.</p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp; Methods: </strong>In this case-control study, 292 diabetic patients were divided into two groups based on angiography reports (150 participants with normal angiogram as the control group and 142 participants with more than 50% stenosis of at least one coronary artery as the case group). The CETP TaqIB genotypes were determined by PCR-RFLP analysis. Fasting blood glucose was measured using glucose oxidase and lipid profile (triglycerides, total cholesterol, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol) by an enzymatic method.</p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Results: </strong>There was no significant difference in the frequency of genotypes and alleles between the case group and controls (the control group: B1B1, 17.3%; B1B2, 63.3%; and B2B2, 19.3%; the case group: B1B1, 18.3%; B1B2, 64.1%; and B2B2, 17.6%) (P=0.92). In the control group, heterozygous participants (genotype B1B2) had higher levels of cholesterol compared with other genotypes (B1B1 and B2B2). Also, the patients with genotype B1B2 had significantly higher weight (P=0.013).</p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Conclusion: </strong>There is no significant correlation between CETP TaqIB polymorphism and the increased risk of coronary artery disease in patients with type 2 diabetes.</p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Keywords</strong>: Cholesterol Ester Transfer Protein, Polymorphism, <a href="http://www.ncbi.nlm.nih.gov/mesh/68003924">Diabetes Mellitus, Type 2</a>, Coronary Artery Disease</p> </div> Cholesterol Ester Transfer Protein, Polymorphism, Diabetes Mellitus, Type 2, Coronary Artery Disease 53 59 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-375&slc_lang=fa&sid=1 Mohammadzadeh, Ghorban 100319475328460011148 100319475328460011148 Yes Hyperlipidemia Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Fatemeh Karimpour 100319475328460011149 100319475328460011149 No Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Mohammad Ali Ghaffari 100319475328460011150 100319475328460011150 No Cellular and Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Alireza Kheirollah 100319475328460011151 100319475328460011151 No Cellular and Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Azadeh Saki 100319475328460011152 100319475328460011152 No School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran