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Correlation between platelet counts, MPV, PDW, PCT and age in acute ischemic stroke patients
Ebrahim Mohammed Abed Ahamid Ahmed, Babker Ahmed Mohamed , Bakri Yousf Mohamed Nour, Babiker Saad Almugadam ,
Volume 18, Issue 4 (Jul-Aug 2024)
Abstract
Background: Acute ischemic stroke occurs when blood clots obstruct blood vessels within the brain. Platelets (Plts) are integral to the pathophysiology of stroke. This research aimed to explore the relationship between Plt quality and Plt indices in the context of acute ischemic stroke.
Methods: This cross-sectional investigation involved 100 patients diagnosed with acute ischemic stroke at Kosti Teaching Hospital and Alyammama Hospitals. The diagnosis was confirmed using brain CT imaging and electrocardiography (ECG). Blood samples were collected in EDTA-containing tubes within 24 hours following the commencement of treatment and were subsequently analyzed for Plt count, mean Plt volume (MPV), Plt distribution width (PDW), and plateletcrit (PCT) utilizing a hematological analyzer. Data were analyzed using GraphPad Prism software.
Results: Platelet counts negatively correlated with PDW [r=-0.074, P=0.459; R=-0.023, P=0.815], MPV [r=-0.130, P=0.194; R=-0.081, P=0.417], and diastolic blood pressure [r= -0.023, P=0.818; R= -0.024, P=0.805]; and positively correlated with PCT [r= 0.103, P=0.308; R=0.143, P=0.155] and diastolic blood pressure [r=0.022, P=0.823; R= 0.008, P=0.932]. Moreover, PDW positively correlated with systolic blood pressure [r=0.105, P=0.298; R= 0.147, P=0.148] and diastolic blood pressure [r=0.146, P=0.145; R=0.173, P=0.084]. Based on Spearman but not Pearson correlation, PDW showed a negative correlation with PCT [r=-0.005, P=0.959; R=0.010, P=0.929].
Conclusion: The study shows a correlation between Plt count and indices in ischemic stroke patients. The research also presented evidence concerning the relationship between diastolic and systolic blood pressure and Plt counts and indices.
 

A Case Series of Melioidosis: The great imitator in MAPIMS hospital, Melmaruvathur, Tamil Nadu, India
Arulananthi Venkataraman Arumugham , Sabarinathan Thiyagarajan , Saleem Mohamed Ali ,
Volume 20, Issue 3 (7-2026)
Abstract
Background: Burkholderia pseudomallei is a saprophytic, aerobic, non-sporing, nonfermenting, facultative intracellular, motile, Gram-negative bacillus found in tropical and subtropical regions. Melioidosis can range from asymptomatic infection to life-threatening disease affecting the internal organs, particularly when host immunity is compromised. Delayed clinical presentation and lack of access to critical care resources in high-prevalence areas contribute significantly to this disease burden. This disease has a high case fatality rate in endemic areas. Written consent was obtained from the patients after the study was explained to them. This case series aimed to increase physicians' awareness of melioidosis in high-risk patients presenting with diverse clinical symptoms, thereby improving diagnostic accuracy and ensuring timely and appropriate treatment.
Case Presentation: Case series: Case 1: a 40-year-old male with septic pulmonary emboli; Case 2: a 72-year-old female with chronic obstructive pulmonary disease and Type II respiratory failure; Case 3: a 25-year-old female with septic arthritis; Case 4: a 69-year-old male with pneumonia and bacteraemia; and Case 5: a 54-year-old male with diabetic nephropathy and chronic kidney disease. Appropriate samples were collected from all cases, and identification of the isolated organisms and antibiotic susceptibility testing were performed using the VITEK 2 automated compact system. The patients were treated with appropriate supportive measures. Among the five cases, three had better outcomes, whereas two cases deteriorated.
Conclusion: This case series emphasizes that clinicians should be aware of the risk of melioidosis, particularly during the rainy season. Diagnostic testing should be improved to ensure timely detection and treatment.

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