en خون شناسی آزمایشگاهی و بانک خون Laboratory hematology گزارش مورد Case Report <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;">Chronic basophilic leukemia (CBL) is a rare disorder and according to the published data, few cases have been reported as primary CBL. Morphologic findings in CBL mostly mimic chronic eosinophilic leukemia and basophils have unusual and dysplastic morphology. A 47-year-old patient was referred to the hospital with gastrointestinal symptoms and bloating. Complete blood count (CBC) showed leukocytosis and marked eosinophilia. After evaluating the peripheral blood smear (PBS), abnormal leukocytes with hypersegmented nuclei along with an increase in eosinophils were observed. For further investigation, the patient was referred to the hematology clinic and underwent bone marrow aspiration and biopsy. After the morphological examination, flow cytometry was performed on the aspiration sample to accurately diagnose the disease. Flow cytometric findings were in favor of CBL. Since morphological findings are unreliable for basophil detection and definite diagnosis, flow cytometry is a reliable method for the precise detection of basophils, especially in CBL.</span></span></div> Basophils, Flow Cytometry, Myeloproliferative Disorders, Chronic Basophilic Leukemia, Chronic Eosinophilic Leukemia 38 40 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1366-1&slc_lang=en&sid=1 Saeid Anvari drsaeidanvari@gmail.com 100319475328460030531 100319475328460030531 No Regenerative Medicine, Organ Procurement and Transplantation Multi-diciplinary Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Setare Kheyrandish masterstar@gmail.com 100319475328460030532 100319475328460030532 No Hematology and Blood Banking Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran Fatemeh Sotudeh f.sotudeh.2000@gmail.com 100319475328460030533 0009-0008-6689-2888 No Langeroud School of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran Hossein Mirpour Hasankiadeh mirhossein07@yahoo.com 100319475328460030534 100319475328460030534 No Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Korosh Khanaki khanaki_korosh_bio@yahoo.com 100319475328460030535 100319475328460030535 No Langeroud School of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran Esmaeil Shahabi Satlsar esmaeilshahabi@yahoo.com 100319475328460030536 100319475328460030536 Yes Langeroud School of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran