en انگل شناسی Parasitology Research Article Research Article <span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> COVID-19 is a respiratory disease pandemic and a major global health problem that can cause acute respiratory distress syndrome (ARDS). Previous studies have shown an inverse link between toxoplasmosis and COVID-19. This study aimed to evaluate the association between COVID-19 and toxoplasmosis infection.<br> <b>Methods:</b> In this cross-sectional descriptive study, samples were taken from 360 patients, 50% of whom were men and 50% were women. Of the patients, 180 were determined to be COVID-19-positive by the ELISA kit, and 180 were in the control group. Some demographic characteristics, such as sex, age range, and occupation, were also recorded.<br> <b>Results:</b> This study was conducted on 180 COVID-19-positive patients, of whom 26.7% were in the 16-30-year age group, 25.1% were self-employed, and 31.7% had anti-<i>Toxoplasma gondii</i> antibodies. Among the 180 control patients, 21.1% had antibodies for <i>T. gondii</i>. Of the 57 patients who were co-infected with both COVID-19 and toxoplasmosis, men had higher infection rates (63.2%) than women (36.8%). There was a significant relationship between co-infections with COVID-19 and toxoplasmosis with occupation, but not with age.<b><span style="font-size:8.0pt"></span></b><br> <b>Conclusion</b>: The study found that people with toxoplasmosis infection have a 1.73 times higher risk of contracting COVID-19. The findings suggest that infectious agents could be a predisposing factor, possibly due to changes in cytokine levels.</span></span> Toxoplasmosis,Infections,Covid-19,Cross-sectional studies 10 12 http://mlj.goums.ac.ir/browse.php?a_code=A-10-883-3&slc_lang=en&sid=1 Ali Ehsan Shahbazi sara123@gmail.com 100319475328460026638 100319475328460026638 No School of Nursing and Midwifery, Saveh University of Medical Sciences, Saveh, Iran Nastaran Barati sara124@gmail.com 100319475328460026639 100319475328460026639 No Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Eissa Soleymani sara125@gmail.com 100319475328460026640 100319475328460026640 No Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Pegah Khandan Del 100319475328460026641 100319475328460026641 No Department of Microbiology, Gorgan Branch, Islamic AzadUniversity, Gorgan, Iran Abolfazl Khandan Del 100319475328460026642 100319475328460026642 No Department of Microbiology, 5th Azar Hospital, Golestan University of Hospital, Golestan University of Medical Sciences, Gorgan, Iran Nemat Azizi 100319475328460026643 100319475328460026643 No School of Nursing and Midwifery, Saveh University of Medical Sciences, Saveh, Iran Behjat ranjouri 100319475328460026644 100319475328460026644 No School of Nursing and Midwifery, Saveh University of Medical Sciences, Saveh, Iran Mehran Bakhtiari 100319475328460026645 100319475328460026645 No Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Seyedmousa Motavallihaghi m_motevali@umsha.ac.ir 100319475328460026646 100319475328460026646 Yes Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran