en فیزیولوژی ورزشی Sport Physiology تحقيقي Original Paper <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><span new="" roman="" times=""><b>Background:</b> Significant economic consequences can lead to various problems and complications, including medical complications. Coronary artery disease (CAD), a serious health threat with increasing prevalence, is a major cause of death and mortality worldwide. This study aimed to investigate the effects of a special training program on cytochrome P450 (CYP) gene expression and reactive oxygen species (ROS) levels in patients with coronary artery bypass surgery.</span><br> <span new="" roman="" times=""><b>Methods:</b> This semi-experimental study was conducted on 16 patients who underwent coronary artery surgery in Babol City, Iran. The patients were selected using a random sampling method and divided into 2 groups: experimental and control groups. The experimental group engaged in an exercise program consisting of 3 sessions per week for a duration of 8 weeks. The expression levels of CYP and ROS genes were measured by the real-time polymerase chain reaction (PCR) method. The analysis was performed by comparing covariances and means.</span><br> <span new="" roman="" times=""><b>Results:</b> ROS gene expression levels significantly decreased in the experimental group than in the control group (P=0.003). However, there was no significant difference in P450 levels between the experimental and control groups (P=0.99).</span><br> <b><span new="" roman="" times="">Conclusion</span></b><span new="" roman="" times="">:</span> <span new="" roman="" times="">Special exercises reduced ROS expression and increased P450 expression in patients who had coronary bypass surgery. There is a probability that special exercises, can effectively prevent heart damage by increasing antioxidant capacity and reducing ROS.</span></span></span></div> Steroid 15-beta-hydroxylase,ROS,Coronary artery bypass,Special training program 12 15 http://mlj.goums.ac.ir/browse.php?a_code=A-10-438-6&slc_lang=en&sid=1 Seyedabdullah Mosavi mosavi_84@yahoo.com 100319475328460032018 100319475328460032018 No Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran Alireza Barari alireza54.barari@gmail.com 100319475328460032019 100319475328460032019 Yes Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran Asie Abbassi Daloii abbasi.daloii@gmail.com 100319475328460032020 100319475328460032020 No Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran