en فیزیولوژی ورزشی Sport Physiology تحقيقي Original Paper <p class="Standard" style="text-align:justify;text-justify:inter-ideograph; line-height:200%"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> Omentin-1 plays an important role in insulin function. Despite numerous studies, the effect of interval training on this adipokine is still vague. This study aimed to elucidate the effect of high-intensity interval training (HIIT) on serum glucose, insulin, insulin resistance (IR), omentin-1 serum levels, and gene expression in the visceral adipose tissue in type 2 diabetic (T2D) rats.<br> <b>Methods:</b> In an experimental study, 20 male rats (8-10 weeks, weight: 250-270 g) were randomly divided into 2 groups: diabetic control (N=10) and diabetic training (N=10). The training protocol was 30 minutes of HIIT (1-min run, 2-min rest) performed 5 days a week for 4 weeks. Fasting blood glucose, insulin resistance, omentin-1 serum level, and gene expression were measured in the visceral fat 48 hours after the last exercise for both groups.<br> <b>Results:</b> The HIIT resulted in lower serum glucose and insulin resistance (P = 0.001), higher serum omentin-1 levels (P = 0.001), and higher visceral fat gene expression (P = 0.004) in the training group compared to the control group.<br> <b>Conclusion</b>: Lower serum glucose and insulin resistance and higher omentin-1 serum levels and gene expression in the training group can prove the effectiveness of HIIT training in T2D, although further research is required.</span></span><br> &nbsp;</p> High-intensity interval training,Insulin resistance,Diabetes Mellitus, Type 2 20 22 http://mlj.goums.ac.ir/browse.php?a_code=A-10-750-1&slc_lang=en&sid=1 Nasrin Ramezani nasrinramezany49@yahoo.com 100319475328460026681 100319475328460026681 No Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, University of Tehran, Tehran, Iran Mahshid Dezhan mahshid_hu@yahoo.com 100319475328460026682 100319475328460026682 No Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, Azad Islamic University, Center Tehran Branch, Tehran, Iran Saide Saadaat Khalili m_s_aram@gmail.com 100319475328460026683 0009-0002-8109-1989 No Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, Azad Islamic University, Saveh Branch, Saveh, Iran Nader Shakeri nsportsport@gmail.com 100319475328460026684 100319475328460026684 No Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, Azad Islamic University, Olum Tahghighat Branch, Tehran, Iran. Kayvan Khoramipour k.khoramipour@gmail.com 100319475328460026685 100319475328460026685 Yes Department of Exercise Physiology, Faculty of Physical Education and Exercise Science, University of Tehran, Tehran, Iran