Medical Laboratory Journal

fa Lack of Association between Selenium Level and Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Breast Cancer Tissue تحقيقي Original Paper <div></div> <div> <p style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); -webkit-text-size-adjust: auto; word-break: break-word; font-family: HelveticaNeue-Regular, Helvetica; margin-top: 0px; margin-bottom: 0px; line-height: 21.600000381469727px;">Background and Objective: HER-2 (human epidermal growth factor receptor 2) is one such gene that can play a role in the development of breast cancer by making HER-2 proteins (receptorson breast cells). Normally, HER-2 receptors control breast cells grow and Division.  HER-2 protein over expression is the cause of up to 20% of breast cancers. The phosphoinositide 3 kinase (PI3K) pathway is important in the oncogenic function of HER-2.  <p style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); -webkit-text-size-adjust: auto; word-break: break-word; font-family: HelveticaNeue-Regular, Helvetica; margin-top: 0px; margin-bottom: 0px; line-height: 21.600000381469727px;">It has been reported compounds including Se, such as selenite significantly attenuated oxidative-stress-induced activation of the PI3K signaling pathways and can exhibit antitumor activity by downregulating PI3K activation. <p class="yiv8929286034s20" style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); -webkit-text-size-adjust: auto; word-break: break-word; font-family: HelveticaNeue-Regular, Helvetica; margin-top: 0px; margin-bottom: 0px; line-height: 21.600000381469727px; direction: rtl;"> In this study, we evaluated Association of tissue selenium level and Human epidermal growth factor receptor 2 (HER-2) expression in breast cancer. <p style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); -webkit-text-size-adjust: auto; word-break: break-word; font-family: HelveticaNeue-Regular, Helvetica; margin-top: 0px; margin-bottom: 0px; line-height: 21.600000381469727px;">methods: <p style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); -webkit-text-size-adjust: auto; word-break: break-word; font-family: HelveticaNeue-Regular, Helvetica; margin-top: 0px; margin-bottom: 0px; line-height: 21.600000381469727px;">Se contents and expression of HER-2 were determined in 30 tissue collected from 30 women diagnosed with breast cancer based on immunohistochemistry (HER-2) and atomic absorption (Se). <p style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); -webkit-text-size-adjust: auto; word-break: break-word; font-family: HelveticaNeue-Regular, Helvetica; margin-top: 0px; margin-bottom: 0px; line-height: 21.600000381469727px;">Results: <p class="yiv8929286034s22" style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); -webkit-text-size-adjust: auto; word-break: break-word; font-family: HelveticaNeue-Regular, Helvetica; margin-top: 0px; margin-bottom: 0px; line-height: 21.600000381469727px;">About 30% of the samples were positive for HER-2 expression. Mean level of tissue selenium in tumors for positive and negative HER-2 was 268.15 µg/l and 206.43µg/l respectively. So, there was no significant association between selenium level and HER-2 expression. (p>0.005) <p style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); -webkit-text-size-adjust: auto; word-break: break-word; font-family: HelveticaNeue-Regular, Helvetica; margin-top: 0px; margin-bottom: 0px; line-height: 21.600000381469727px;">Conclusion: <p style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); -webkit-text-size-adjust: auto; word-break: break-word; font-family: HelveticaNeue-Regular, Helvetica; margin-top: 0px; margin-bottom: 0px; line-height: 21.600000381469727px;">There is no Association of tissue selenium level and HER-2 expression in breast cancer. <p style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); -webkit-text-size-adjust: auto; word-break: break-word; font-family: HelveticaNeue-Regular, Helvetica; margin-top: 0px; margin-bottom: 0px; line-height: 21.600000381469727px;">Keyword: <p style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); -webkit-text-size-adjust: auto; word-break: break-word; font-family: HelveticaNeue-Regular, Helvetica; margin-top: 0px; margin-bottom: 0px; line-height: 21.600000381469727px;">Selenium, HER-2, breast cancer </div> Selenium, HER-2, breast cancer 12 14 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-536&slc_lang=fa&sid=1 Sanaz Salar amoli 100319475328460015290 100319475328460015290 No cancer research center,Golestan University of Medical Sciences, Gorgan,Iran Sima Besharat 100319475328460015291 100319475328460015291 No cancer research center,Golestan University of Medical Sciences, Gorgan,Iran Amir nader Emami razavi 100319475328460015292 100319475328460015292 No cancer research center,Tehran University of Medical Sciences, Tehran, Iran AliAsghar Ayatollahi 100319475328460015294 100319475328460015294 No Golestan University of Medical Sciences, Medical Laboratory Sciences Research Center, Gorgan, Iran Hamidreza Joshaghani Hr_joshaghani@yahoo.com 100319475328460015293 100319475328460015293 Yes Golestan University of Medical Sciences, Medical Laboratory Sciences Research Center, Gorgan, Iran